System And Method For Radiation Biodosimetry On Nail Clippings Using Electron Paramagnetic Resonance Spectroscopy

摘要

A system and method are disclosed for post-exposure radiation biodosimetry on subjects using electron paramagnetic resonance (EPR) spectroscopy of nail clippings from the subjects. Basis spectra averaged from a plurality of nail clipping measurements are used to spectrally decompose an EPR-measured signal and identify a radiation-induced signal (RIS). The RIS is used to determine an exposure dose from a standard curve. A collection apparatus provides for harvesting and storing nail clippings in a dry, oxygen-reduced, environment to prevent sample degradation. The collection apparatus includes a container with an atmosphere isolated from external atmosphere and a sample bag impermeable to oxygen and water vapor. The sample bag includes an oxygen absorber and a desiccant for storing nail clippings with minimal exposure to oxygen and water vapor, thereby retaining a stable EPR signal.

主权项

1. A method for radiation biodosimetry on at least one nail clipping of a subject using electron paramagnetic resonance (EPR) spectroscopy, comprising:
receiving an EPR-measured spectrographic signal from an EPR spectroscopy measurement of the nail clipping; spectrally decomposing the EPR-measured spectrographic signal, thereby identifying a radiation-induced signal (RIS) component of the EPR-measured signal and separating the RIS from a mechanically-induced (MIS) signal component of the EPR-measured spectrographic signal; and subtracting a background signal from the RIS, thereby generating a background-subtracted RIS; and determining exposure dose from the background-subtracted RIS.