摘要 |
Provided is a compound of formula (I)[Formula (I) should be inserted here], in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/ or lactate dehydrogenase B (LDHB) activity in a cell. |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;VANDERBILT UNIVERSITY |
发明人 |
MALONEY, DAVID J.;JADHAV, AJIT;BANTUKALLU, GANESHA RAI;BRIMACOMBE, KYLE RYAN;MOTT, BRYAN T.;YANG, SHYH MING;URBAN, DANIEL JASON;HU, XIN;SIMEONOV, ANTON;KOUZNETSOVA, JENNIFER L.;WATERSON, ALEX GREGORY;SULIKOWSKI, GARY ALLEN;KIM, KWANGHO;CHRISTOV, PLAMEN;JANA, SOMNATH |