| 发明名称 |
EPHA3 AND MULTI-VALENT TARGETING OF TUMORS |
| 摘要 |
Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some embodiments, the at least one effector molecule comprises a therapeutic agent, a nanoparticle, a detectable group, a lipid, or a liposome. In some embodiments, the construct is a fusion protein and/or a covalent conjugate. Further provided is a construct comprising in combination: a ligand that binds to EphA2, EphA3 and/or EphB2; a ligand that binds to IL-13Rα2; and at least one effector molecule. Also provided are methods of use thereof for treating cancer. |
| 申请公布号 |
US2016297863(A1) |
申请公布日期 |
2016.10.13 |
| 申请号 |
US201415035560 |
申请日期 |
2014.11.11 |
| 申请人 |
WAKE FOREST UNIVERSITY HEALTH SCIENCES |
发明人 |
Debinski Waldemar;Tome Carla Lema;Ferluga Sara;Sonawane Poonam S. |
| 分类号 |
C07K14/705;G01N33/574;C07K14/54 |
主分类号 |
C07K14/705 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A construct comprising, in combination:
a ligand that binds to EphA2, EphA3, and EphB2; and at least one effector molecule. |
| 地址 |
Winston-Salem NC US |
