| 主权项 |
1. A compound having structural formula I: or a pharmaceutically acceptable salt thereof, wherein: Z is ═C(R2)—; each of X1 and X2 is ═C(R3)—, wherein two R3 are taken together with the carbon atoms to which they are bound to form an aryl, heteroaryl, or carbocyclyl fused to the ring comprising X1, X2 and X3; X3 is ═C(R6)—; no more than one of X1, X2, and X3 is ═N—; each R1 and R2 is independently selected from hydrogen, halo, —OH, —CN, C1-C4 alkyl, —O—(C1-C4 alkyl), —N(R7)2, —(C0-C4 alkylene)-aryl, —(C0-C4 alkylene)-heteroaryl, —(C0-C4 alkylene)-heterocyclyl, and —(C0-C4 alkylene)-carbocyclyl; or
one R1 and R2 are taken together with atoms to which they are bound to form an aryl, heteroaryl, heterocyclyl, or carbocyclyl ring; R6 is selected from hydrogen, halo, —CN, —(C0-C4 alkylene)-R8, —(C2-C6 alkenyl or alkynyl)-R9, —(C1-C4 alkylene)-O—R9, —(C1-C4 alkylene)-O—(C1-C4 alkylene)-R8, —O—(C0-C4 alkylene)-R9, —O—(C2-C4 alkylene)-O—R8, —O—(C1-C4 alkylene)-R9, —(C0-C4 alkylene)-N(R7)2, —(C0-C4 alkylene)-C(O)—O—R9, —(C0-C4 alkylene)-O—C(O)—R9, —(C0-C4 alkylene)-C(O)—N(R7)2, —(C0-C4 alkylene)-N(R9)—C(O)—R9, —O—(C1-C4 alkylene)-C(O)—N(R7)2, —O—(C2-C4 alkylene)-N(R9)—C(O)—(R7), —(C0-C4 alkylene)-S(O)—R8, —(C0-C4 alkylene)-S(O)2—R8 and —(C0-C4 alkylene)-S(O)2—N(R7)2; Rx is Q, —S(O)2-Q, —C(O)-Q, or —CH(R4)(R5); Q is selected from aryl, heteroaryl, heterocyclyl, or carbocyclyl; R4 is selected from C2-C6 alkyl, —CH2—O—(C1-C4 alkyl) and —(C0-C6 alkylene)-Q, wherein one or two methylene units in the alkyl or alkylene portion of R4 are optionally and independently replaced by —O—, —S—, —S(═O)—, —S(═O)2—, or —N(R10)—; or R5 is selected from hydrogen, —(C0-C6 alkylene)-Q, and C1-C6 alkyl, wherein one or two methylene units in R5 are optionally and independently replaced by —O—, —S—, —S(═O)—, —S(═O)2—, or —NR10—; each R7 is independently selected from —(C0-C4 alkylene)-R9, —(C0-C4 alkylene)-O—R9, —S(O)2—R8, —C(═O)—R8, —C(═O)—N(R9)2, —(C1-C4 alkylene)-O—C(═O)—R8 and —(C0-C4 alkylene)-C(═O)—O—R9; or
two R7 are taken together with the nitrogen atom to which they are commonly bound to form an optionally substituted heterocyclyl or heteroaryl; R8 is selected from C1-C4 alkyl, aryl, heteroaryl, carbocyclyl and heterocyclyl; R9 is selected from hydrogen or R8; R10 is selected from hydrogen, C1-C4 alkyl, —S(═O)2—R9, —C(═O)—R8, —C(═O)—N(R9)(R12), and —C(═O)—O—R11; R11 is selected from unsubstituted C1-C4 alkyl and C1-C4 haloalkyl; R12 is selected from hydrogen, unsubstituted C1-C4 alkyl and C1-C4 haloalkyl; wherein unless otherwise designated any alkyl, alkylene, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl or carbocyclyl portion of the compound is optionally substituted; and wherein: when each R1 is methyl, Z is ═C(H)—, X3 is ═N—, and Rx is phenyl or 4-fluorophenyl; then the R3 of X1 and the R3 of X2 are not taken together to form unsubstituted C5-C7 cycloalkyl fused to the ring comprising X1, X2 and X3. |
