| 发明名称 |
Methods of using isotopically labelled isoniazid for the diagnosis of mycobacterial infections |
| 摘要 |
The present invention is directed to methods of diagnosing the presence or absence of a bacterial infection in a patient, in particular, a tuberculosis infection, by measuring exhaled, isotopically labeled nitrogen gas after administration of isotopically labeled isoniazid. |
| 申请公布号 |
US9453253(B2) |
申请公布日期 |
2016.09.27 |
| 申请号 |
US201314404134 |
申请日期 |
2013.03.07 |
| 申请人 |
STC.UNM;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
Timmins Graham;Choi Seong;Sharp Zachary;Atudorei Viorel;Maiga Mamoudou;Bishai William |
| 分类号 |
G01N33/60;C12Q1/04;G01N33/569;C12Q1/28 |
主分类号 |
G01N33/60 |
| 代理机构 |
|
代理人 |
Coleman Henry D.;Sudol R. Neil |
| 主权项 |
1. A method for determining the presence or absence of a mycobacterial infection in the lungs of a patient comprising:
administering to the lungs of the patient a diagnostically effective amount of 15N-labeled isoniazid and optionally, isotopically labeled urea; collecting one or more samples of exhaled breath from the subject; and determining an amount of 15N-labeled nitrogen gas in said samples; said amount indicating presence or absence of the mycobacterial infection in the lungs of the patient. |
| 地址 |
Albuquerque NM US |
