Genetic Markers for Antipsychotic Induced Weight Gain and Methods for Use Thereof

摘要

Provided is a method of predicting a subject's weight response to antipsychotic drug treatment by obtaining a biological sample comprising genomic DNA from the subject and determining the presence or absence of one or more polymorphisms in the GABRA2 gene of the subject, wherein the presence of said one or more polymorphisms is predictive of the subject's weight change in response to antipsychotic drug treatment. The method also may comprise additional steps including treating the subject. Kits and components thereof are also provided.

主权项

1. A method of predicting a subject's weight change in response to antipsychotic drug treatment comprising,
a) obtaining a biological sample comprising genomic DNA from the subject; and b) determining the presence or absence of one or more polymorphisms in the GABRA2 gene of the subject or the complement thereof, wherein the presence of said one or more polymorphisms is predictive of the subject's weight response to antipsychotic drug treatment.