Thermo-controllable high-density chips for multiplex analyses

摘要

The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.

主权项

1. A chip for varying and/or maintaining a reaction sample comprising an array of thermo-controllable units, wherein the chip has a surface density of at least about one thermo-controllable unit per 1 mm2, and wherein a unit within the array comprises a micro well for receiving and confining the reaction sample and a heating element in thermal contact with said micro well.