发明名称 |
COMPUTATION PIPELINE OF LOCATION-DEPENDENT VARIANT CALLS |
摘要 |
The present disclosure provides a computer-implemented method for analyzing variants from a plurality of nucleic acid sequence reads using a computation pipeline, which comprises a module depending on a location-dependent parameter. The method comprises executing on a processor the steps of: receiving a plurality of nucleic acid sequence reads comprising at least a first nucleic acid sequence read and a second nucleic acid sequence read; mapping the first nucleic acid sequence read and the second nucleic acid sequence read to a first location and a second location in a genome, respectively; setting a first value and a second value for the location-dependent parameter on the basis of the first location and the second location in the genome, respectively; passing the first nucleic acid sequence read and the second nucleic acid sequence read through the module using the first value and the second value, respectively; and generating a variant call. |
申请公布号 |
US2016283655(A1) |
申请公布日期 |
2016.09.29 |
申请号 |
US201615080538 |
申请日期 |
2016.03.24 |
申请人 |
Sentieon Inc. |
发明人 |
Ye Jun;Zhou Wei;Chen Luoqi;Feng Hanying;Chen Hong;Liu Xiaofeng |
分类号 |
G06F19/22;C40B30/02 |
主分类号 |
G06F19/22 |
代理机构 |
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代理人 |
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主权项 |
1. A computer-implemented method for analyzing variants from a plurality of nucleic acid sequence reads using a computation pipeline, said computation pipeline comprising a module depending on a location-dependent parameter, said method comprising executing on a processor the steps of:
receiving a plurality of nucleic acid sequence reads comprising at least a first nucleic acid sequence read and a second nucleic acid sequence read; mapping the first nucleic acid sequence read and the second nucleic acid sequence read to a first location and a second location in a genome, respectively, wherein the first location is different from the second location; setting a first value and a second value for the location-dependent parameter on the basis of the first location and the second location in the genome, respectively, wherein the first value is different from the second value; passing the first nucleic acid sequence read and the second nucleic acid sequence read through the module, using the first value and the second value, respectively; and generating a variant call. |
地址 |
Mountain View CA US |