发明名称 |
Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition |
摘要 |
The present invention provides methods for reducing the amidolytic and anti-complement activity (ACA) content of an immunoglobulin composition through the use of cation exchange chromatography. In a specific embodiment, the invention provides methods for reducing the Factor XI and/or Factor XIa and/or ACA content of an immunoglobulin composition by collecting the leading portion of a cation exchange eluate. The present invention also provides immunoglobulin composition having reduced levels of amidolytic activity, Factor XI, and/or Factor XIa, and/or ACA content. |
申请公布号 |
AU2012300220(C1) |
申请公布日期 |
2016.11.10 |
申请号 |
AU20120300220 |
申请日期 |
2012.08.27 |
申请人 |
Baxalta GmbH;Baxalta Incorporated |
发明人 |
Teschner, Wolfgang;Butterweck, Harald Arno;Koelbl, Bernhard;Hofbauer, Lucia;Schwarz, Hans-Peter |
分类号 |
C07K16/06 |
主分类号 |
C07K16/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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