| 摘要 |
<p>Campothecin-peptide derivatives (I) are new. Campothecin-peptide derivatives of formula (I) are new. R 1hydrogen or hydroxy; R 2hydrogen, amino, nitro or N,N-dimethylaminomethyl; R 3hydrogen or ethyl; R 4hydrogen, alkyl or aryl; R 5hydrogen, optionally substituted alkyl or aryl; P 1, P 3Ala, Gly, Leu, Ile, norleucine (Nle) and/or Phe; P 2, P 4Leu, Ile, Nle and/or Phe; X aaamino acid with a basic sidechain; n : 0-3; m : 1-3; k : 0-5; p : 0-6; and PM : protein-binding group. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.</p> |
