发明名称 |
Human anti-IL-33 neutralizing monoclonal antibody |
摘要 |
The purpose of the present invention is to provide an antibody exhibiting antagonistic action against IL-33, in particular, an isolated human anti-IL-33 neutralizing monoclonal antibody or fragment thereof in which the amino acid sequences of framework regions are germline amino acid sequences or amino acid sequences of combinations of said germline amino acid sequences. Accordingly, epitopes are identified for a plurality of anti-IL-33 monoclonal antibodies, human anti-IL-33 neutralizing monoclonal antibodies are obtained, and mutations are introduced into complementarity determining regions of the human anti-IL-33 neutralizing monoclonal antibodies to specify a complementarity determining region exhibiting high affinity to IL-33. The specified complementarity determining region is used to obtain a human anti-IL-33 neutralizing monoclonal antibody in which the amino acid sequences of framework regions are germline amino acid sequences or amino acid sequences of combinations of said germline amino acid sequences. |
申请公布号 |
AU2014370883(A1) |
申请公布日期 |
2016.06.16 |
申请号 |
AU20140370883 |
申请日期 |
2014.12.26 |
申请人 |
MITSUBISHI TANABE PHARMA CORPORATION |
发明人 |
FUJINO, YASUHIRO;YOSHIKAWA, TSUTOMU;OCHI, HIROSHI |
分类号 |
C12N15/09;A61K39/395;A61P1/04;A61P11/00;A61P11/06;A61P13/12;A61P17/00;A61P17/04;A61P19/02;A61P21/02;A61P29/00;A61P37/06;A61P43/00;C07K7/08;C07K14/54;C07K16/24 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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