DEVICES, SYSTEMS AND METHODS FOR TISSUE ENGINEERING OF LUMINAL GRAFTS

摘要

The disclosure of the present application provides devices, systems, and methods for replacing damaged or compromised blood vessels and engineering luminal grafts for various medical applications. Such devices are capable of providing viable, small-diameter grafts for use in anastomotic procedures and comprise a tubular construct consisting largely of elastin and some collagen fibers and having at least one diameter of less than or equal to about 5 mm. In one exemplary embodiment, the graft comprises at least one layer of pulmonary ligament tissue and/or pulmonary visceral pleura. Systems and methods for the manufacture of the graft are also provided, which include the use of at least one layer of tissue, a mandrel and a closure mechanism.

主权项

1. A luminal graft comprising a generally tubular element configured for plasma and/or blood cells to flow therethrough and comprising biological tissue having elastin fibers and collagen fibers, with the elastin fibers being a dominant component thereof.