发明名称 |
PROCESS FOR THE PREPARATION OF (R)-(-)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND OF PREGABALIN AND SYNTHESIS INTERMEDIATES |
摘要 |
This invention relates to the preparation of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid, in particular, the resolution of the acid racemate by means of salification with optically active amines and subsequent acidification to give the (R) enantiomer of the acid; this invention also concerns the salt intermediates formed with said amines and the conversion of said (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid into biologically active molecules such as pregabalin. |
申请公布号 |
EP2035368(A1) |
申请公布日期 |
2009.03.18 |
申请号 |
EP20070766518 |
申请日期 |
2007.06.06 |
申请人 |
LABORATORIO CHIMICO INTERNAZIONALE S.P.A. |
发明人 |
SALVI, ANNIBALE;NARDI, ANTONIO;DE ANGELIS, BRUNO |
分类号 |
C07C211/27;C07C215/28;C07C227/32;C07C229/08;C07C231/20;C07C233/05 |
主分类号 |
C07C211/27 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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