ENDOGENOUS RETROVIRUS UP-REGULATED IN PROSTATE CANCER

摘要

PROBLEM TO BE SOLVED: To provide improved materials and methods that can be used in the diagnosis, prevention and treatment of prostate cancer. SOLUTION: A method for diagnosing cancer, especially prostate cancer, the method comprises the step of detecting in a patient sample the presence or absence of an expression product of a human endogenous retrovirus (PCAV) located at megabase 20.428 on chromosome 22. A method of screening for compounds with activity against cancer, comprises: contacting a test compound with a tissue sample derived from a cell in which expression of the human endogenous retrovirus located at megabase 20.428 on chromosome 22 is up-regulated; and monitoring expression of the retrovirus in the sample, wherein a decrease in expression indicates anti-cancer efficacy of the test compound. COPYRIGHT: (C)2009,JPO&INPIT