摘要 |
The hemitartrate salt of a compound represented by the following structural formula:
(Formula I Hemitartrate), which may be used in pharmaceutical applications, are disclosed. Particular single crystalline forms of the Formula (I) Hemitartrate are characterized by a variety of properties and physical measurements. As well, methods of producing crystalline Formula (I) Hemitartrate, and using it to inhibit glucosylceramide synthase or lowering glycosphingolipid concentrations in subjects to treat a number of diseases, are also discussed. Pharmaceutical compositions are also described. |
申请人 |
Genzyme Corporation |
发明人 |
Liu, Hanlan;Willis, Chris;Bhardwaj, Renu;Copeland, Diane P.;Harianawala, Abizer;Skell, Jeffrey;Marshall, John;Kochling, Jianmei;Palace, Gerard;Peterschmitt, Judith;Siegel, Craig;Cheng, Seng |