AZACYCLIC CONSTRAINED ANALOGS OF FTY720

摘要

Small molecules comprised of azacyclic constrained analogs of FTY720 are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, leukemia, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.

主权项

1. A compound comprising: wherein: R1 is an optional functional group selected from an alkyl chain, (CH2)nOH, CHOH-alkyl, CHOH-alkyne, and (CH2)nOMe; R2 is an aliphatic chain (C6-C10); R3 is a mono-, di-, tri- or quad-aromatic substituent comprising hydrogen, halogen, alkyl, alkoxy, azide (N3), ether, NO2, or cyanide (CN); R4 is an optional alcohol (CH2OH) with R1; L is O—CH2; Me is an alkyl, alkene or alkyne; n is an independently selected integer selected from the group of 1, 2, or 3; and wherein the phenyl can be moved along the R2 or R3 carbon chain.