发明名称 |
OLIGONUKLEOTIDE DIE EINE ANTISENSE-SEQUENZ ENTHALTEN DIE DURCH EINE SEKONDÄRSTRUKTUR STABILISIERT SIND UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DIE SIE ENTHALTEN |
摘要 |
<p>Oligonucleotides capable of modifying or inhibiting in vivo or in vitro expression of a target gene wherein the oligonucleotide has an antisense sequence, at least one secondary structure, and optionally a supplementary nucleotide sequence located at one and/or both ends of the antisense sequence and wherein the secondary structure disintegrates upon attachment of the oligonucleotide to a target nucleic acid; a pharmaceutical composition containing such an oligonucleotide as an active ingredient; and a method of treatment using such an oligonucleotide.</p> |
申请公布号 |
AT328074(T) |
申请公布日期 |
2006.06.15 |
申请号 |
AT20000910916T |
申请日期 |
2000.03.09 |
申请人 |
BIOALLIANCE PHARMA (S.A.);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSTITUT GUSTAVE ROUSSY -IGR- |
发明人 |
MALVY, CLAUDE;MAKSIMENKO, ANDREI;HELIN, VALERIE;GOTTIKH, MARINA |
分类号 |
C12N15/09;A61K31/711;A61K47/48;A61K48/00;A61P31/12;A61P31/14;A61P35/00;C12N15/113;(IPC1-7):C12N15/11;A61K31/713 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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