BENZENE COMPOUNDS DISUBSTITUTED WITH CYCLIC GROUPS AT THE 1- AND 2-POSITIONS.

摘要

Compounds represented by the general formula (1) or (100) have excellent inhibitory activities against cell adhesion and cell infiltration and are useful as therapeutic or preventive agents for various inflammatory and autoimmune diseases caused by the adhesion and infiltration of white blood cells, for example, inflammatory diseases of intestine (particularly ulcerative colitis or CrohnaCOs disease), irritable bowel syndrome, rheumatic arthritis, psoriasis, multiple sclerosis, asthma, and atopic dermatitis: (1) (100) wherein R10 is optionally substituted cycloalkyl or the like; R20, R21, R22 and R23 are each hydrogen, alkyl, alkoxy, or the like; R30, R31 and R32 are each hydrogen, alkyl, oxo, or the like; and R40 is optionally substituted alkyl or the like.