发明名称 |
PROCESS FOR THE SYNTHESIS OF CYCLIC CARBAMATES |
摘要 |
The invention is directed to a process for the preparation of a cyclic carbamate starting with a chiral propargylic alcohol and/or a suitable salt thereof, which is reacted with a cyclisation agent selected from phosgene, diphosgene, triphosgene and mixtures thereof, and in that the reaction is carried out in the presence of an aqueous base, and a water-immiscible organic solvent, said organic solvent mainly comprising at least one compound selected from C 2-5 -alkyl C 2-5 -carboxylates and mixtures of at least one C 2-5 -alkyl C 2-5 -carboxylate with at least one C 5-8 -alkane. Another aspect of the invention is directed to a process for the synthesis of said cyclic carbamate starting described above, wherein also a process for the preparation of the chiral propargylic alcohol is provided. |
申请公布号 |
HK1183871(A1) |
申请公布日期 |
2016.11.04 |
申请号 |
HK20130111349 |
申请日期 |
2013.10.08 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
BRENNER, Meinrad;CARREIRA, Erick, M.;CHINKOV, Nicka;LORENZI, Miriam;WARM, Aleksander;ZIMMERMANN, Lothar |
分类号 |
C07D |
主分类号 |
C07D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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