发明名称 |
METHODS FOR INCREASING NEURONAL SURVIVAL |
摘要 |
Described are methods of treating a subject after acute trauma to the head, viral encephalitis, or other causes of acute neurodegeneration, and/or after acute vascular insults, including ischemic and hemorrhagic strokes, the method comprising administering inhibitors of BACE1; an inhibitory oligonucleotide targeting BACE1; and/or an inhibitory oligonucleotide targeting APLP2. Also described are methods for treating a subject who is at high risk for head trauma, including administering a prophylactically effective amount (i.e., an amount sufficient to reduce the risk of developing or reduce the severity or duration of symptoms of head trauma) of one or more of an inhibitor of BACE1; an inhibitory oligonucleotide targeting BACE1; or an inhibitory oligonucleotide targeting APLP2. |
申请公布号 |
US2016235843(A1) |
申请公布日期 |
2016.08.18 |
申请号 |
US201415025648 |
申请日期 |
2014.10.03 |
申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
Albers Mark William;Cao Luxiang |
分类号 |
A61K39/395;A61K31/713;A61K31/366;A61K31/704;A61K31/351 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating a subject after acute trauma to the head, viral encephalitis, or other causes of acute neurodegeneration, and/or after acute vascular insults, including ischemic and hemorrhagic strokes, the method comprising administering a therapeutically effective amount of one or more of:
an inhibitor of BACE1; an inhibitory oligonucleotide targeting BACE1; or an inhibitory oligonucleotide targeting APLP2. |
地址 |
Boston MA US |