Compositions for Treating Dry Eye Disease

摘要

The present invention provides a pharmaceutical composition, and methods of use thereof, for treating ocular boundary deficiency, symptoms associated therewith, or an undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface. The pharmaceutical composition of the present invention comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The pharmaceutical composition of the present invention may also comprise one or more ophthalmically acceptable agents selected from the group consisting of an ophthalmically acceptable demulcent, excipient, astringent, vasoconstrictor, emollient, sodium hyaluronate, hyaluronic acid, and surface active phospholipids, in a pharmaceutically acceptable carrier for topical administration.

主权项

1. An eye drop suitable for topical application to an ocular surface comprising:
PRG4 or a lubricating fragment thereof comprising glycosylated repeats of the sequence KEPAPTT at a concentration effective to relieve eye discomfort, dry eye disease, or symptoms associated therewith, and an ophthalmically balanced salt solution comprising one or more of potassium, magnesium, bicarbonate, and calcium.