AGONISTS OF GUANYLATE CYCLASE USEFUL FOR DOWNREGULATION OF PRO-INFLAMMATORY CYTOKINES

摘要

This invention provides a method to prevent, control, and/or treat an inflammatory disease or disorder by administering at least one agonist of guanalyte cyclase receptor, or pharmaceutical compositions thereof, either alone or either concurrently or sequentially with another compound or an active agent used to treat the disease or disorder, and/or with an inhibitor of cGMP-dependent phosphodieasterases.

主权项

1. A composition comprising a guanylate cyclase receptor agonist (GCRA) peptide comprising of the sequence of any one of Tables 1-7 and a NF-κB inhibitor, a c-Src tyrosine kinase inhibitor, a 5-ASA agent, a c-Myc inhibitor, or an Ikk inhibitor.