SYNTHESIS AND APPLICATION OF BORNYL FERULATE

摘要

Provided are synthesis and application of bornyl ferulate. A synthesis technology enables ferulic acid, protected by a phenolic hydroxyl group, and borneol to perform condensation reaction, and an obtained product is de-protected to obtain bornyl ferulate. Another synthesis technology performs reaction between halogenated bornyl acetate and an organophosphorus agent, and then performs wittig reaction between an obtained wittig phosphorous agent and 3-methoxyl-4-hydroxy benzaldehyde, so as to obtain bornyl ferulate. The synthesis technologies of the present invention are simple, raw materials are economic, easy to obtain, non-toxin and harmless, and the synthesis process is easy to control and applicable to large-scale industrial production. In addition, the present invention also provides application of bornyl ferulate in preparation of a medicine for treating cerebrovascular diseases. Specifically, the inventor discovers that the bornyl ferulate is capable of effectively relieving the brain blood circulation disorder disease of a patient with stroke, achieves a good protection effect on brain nerves of the patient, and has a good clinical application prospect.