发明名称 |
ANTAGONISTS OF ENDOTHELIAL DIFFERENTIATION GENE SUBFAMILY 3 (EDG-3, S1P3) RECEPTORS FOR PREVENTION AND TREATMENT OF OCULAR DISORDERS |
摘要 |
Antagonists of S1P3 (Edg-3) receptors are provided for attenuation of Smad signaling in a method of down-regulation of receptor signaling and downstream decreased production of connective tissue growth factor in ocular disorders involving CTGF accumulation. Ocular disorders involving inappropriate CTGF accumulation include ocular hypertension, glaucoma, glaucomatous retinopathy, optic neuropathy, macular degeneration, diabetic retinopathy, choroidal neovascularization, proliferative vitreoretinopathy and ocular wound healing, for example. Such disorders are treated by administering antagonists of the present invention. |
申请公布号 |
WO2008014338(A3) |
申请公布日期 |
2008.12.24 |
申请号 |
WO2007US74351 |
申请日期 |
2007.07.25 |
申请人 |
ALCON RESEARCH, LTD.;FLEENOR, DEBRA, L.;SHEPARD, ALLAN, R.;PANG, IOK-HOU |
发明人 |
FLEENOR, DEBRA, L.;SHEPARD, ALLAN, R.;PANG, IOK-HOU |
分类号 |
A61K31/17;A61K31/426;A61K31/54;A61P27/02;A61P27/06 |
主分类号 |
A61K31/17 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|