| 摘要 |
The invention relates to an expression platform for expressing an endolysin. In particular the invention relates to a cyanobacterial expression platform for expressing an endolysin with antibacterial activity, particularly against Propionibacterium acnes which is a causative bacterium for acne vulgaris. The cyanobacterial expression platform is particularly well suited for large-scale production of the endolysin, or fragment, variant, derivative or fusion thereof. Such large-scale production may involve the use of a photobioreactor (PBR). In some embodiments, the cyanobacterial expression platform comprises a strain of Synechocystis sp., such as Synechocystis PCC 6803. The invention provides polypeptide comprising the amino acid sequence of SEQ ID No: 1, or a fragment, variant, derivative or fusion thereof for use in the treatment and/or prevention of a bacterial infection, such as bacterial infection which is caused by Propionibacterium acnes. |
