SAMPLE OPTICAL PATHLENGTH CONTROL USING A NONINVASIVE ANALYZER APPARATUS AND METHOD OF USE THEREOF

摘要

A noninvasive analyzer apparatus and method of use thereof is described for spatially separating light for use in noninvasively determining an analyte concentration of a subject through use of detectors linked to multiple controlled sample illumination zone to sample detection zone distances. The controlled radial separation of illumination and detection zones yields reduced deviation in total observed optical pathlength and/or control of pathlengths in a desired tissue volume for each element of a set of detector elements. Performance using the discrete detection zones is enhanced using a combination of segmented spacers, arcs of detector elements, use of micro-optics, use of optical filters associated with individual detector elements, control of detector response shapes, and/or outlier analysis achievable through use of multiple separate and related observed signals of a detector array.

主权项

1. An apparatus for spatially separating light for use in noninvasively determining an analyte concentration of a subject, comprising:
a near-infrared noninvasive analyzer, comprising:
a near-infrared source;a coupling optic configured to couple light from said near-infrared source with an illumination zone on the subject during use;a plurality of optically defined detection zones, comprising:
a first detection zone at a first radial distance from the illumination zone; anda second detection zone at a second radial distance from the illumination zone; anda set of detectors, comprising:
a first plurality of detectors optically configured to detect light from said first detection zone; anda second plurality of detectors optically configured to detect light from said second detection zone.