| 摘要 |
<p>The present invention provides radioactive metal heterocomplexes of formula (I): Ä(Me=N-R)L<1>L<2>Ü<+>Z<-> wherein Me, R, L<1> L<2> and Z<-> have the meanings indicated in the description. The complexes include a trivalent radioactive metal-imido group, typically a technetium- or rhenium-imido group, strongly stabilized by the presence of an ancillary tridentate hetero-diphosphine ligand L<1>, which allows the formation of substitution-inert Ä(Me=N-R)L<1>Ü moieties. Such moieties are fixed in an intermediate Ä(Me=N-R)Y2L<1>)Ü<+> compound which contains two labile, cis-positioned, Y ligands, where Y is preferably an halide group. The latter are easily replaced by a bidentate ligand L<2> to give the final Ä(Me=N-R)L<1>L<2>Ü<+>Z<-> heterocomplexes. The complexes of the invention are useful for the preparation of radiopharmaceuticals: in fact, a bioactive fragment which confers biological target-seeking properties can be introduced either on the L<2> framework or the imido R group.</p> |
