CD19 ANTIBODIES AND THEIR USES

摘要

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD 19 with high affinity. Nucleic acid molecules encoding such CD 19 antibodies, expression vectors, host cells and methods for expressing the CD 19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD 19 antibodies are also provided. Methods for detecting CD 19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.