发明名称 |
EXOSOMAL LOADING USING HYDROPHOBICALLY MODIFIED OLIGONUCLEOTIDES |
摘要 |
In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided. |
申请公布号 |
WO2015161184(A8) |
申请公布日期 |
2016.12.08 |
申请号 |
WO2015US26350 |
申请日期 |
2015.04.17 |
申请人 |
UNIVERSITY OF MASSACHUSETTS |
发明人 |
KHVOROVA, Anastasia;ARONIN, Neil;DIDIOT, Marie, Cecile |
分类号 |
C12N15/88 |
主分类号 |
C12N15/88 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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