| 摘要 |
<p>A novel intermediate which is for use in efficiently producing a 1beta-methylcarbapenem compound for oral administration; and a process for producing the intermediate. The process, which is for producing a novel beta-lactam compound represented by the general formula (4), is characterized by reacting a beta-lactam compound represented by the general formula (5) as a starting material with a compound represented by the general formula (6) in the presence of a base to obtain a novel beta-lactam compound represented by the general formula (1), protecting the hydroxy group, subsequently cyclizing the protected compound in the presence of a strong base, reacting the cyclized compound with diphenylphosphoryl chloride to obtain a novel beta-lactam compound represented by the general formula (3), and removing the protective group therefrom. (5) (6) (1) (3) (4) (In the formulae, R1 represents trimethylsilyl or triethylsilyl; R2 represents aryl or heteroaryl; R3 represents C1-10 alkyl or C3- 10 cycloalkyl; and X represents halogeno.)</p> |
