OCULAR DELIVERY SYSTEMS AND METHODS

摘要

Described here are systems and methods for accessing Schlemm's canal and for delivering an ocular device, tool, or fluid composition therein. The ocular devices may maintain the patency of Schlemm's canal without substantially interfering with transmural fluid flow across the canal. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. Some systems described here may be configured to cut or tear the trabecular meshwork with the body of an elongate member located within Schlemm's canal. Other tools for disrupting these tissues and minimally invasive methods for treating medical conditions associated with elevated intraocular pressure, including glaucoma, are also described.

主权项

1. A system for introducing a fluid composition into Schlemm's canal, comprising:
a housing; a cannula attached to the distal end of the housing and comprising a distal tip; a flexible elongate member comprising a lumen and a distal end, wherein the distal end is slidable within the cannula between a retracted position and an extended position, wherein the distal end is within the cannula in the retracted position and distal to the distal tip of the cannula in the extended position; a reservoir comprising a fluid composition, wherein the reservoir is fluidly connected to the lumen of the flexible elongate member; and a drive assembly configured to simultaneously move the flexible elongate member from the extended position to the retracted position and deliver the fluid composition from the reservoir through the lumen of the flexible elongate member.