CELL STRAIN HAVING INCREASED VIRUS PRODUCTION ABILITY AND PRODUCTION METHOD THEREFOR

摘要

The present invention relates to a cell line having an increased ability to produce virus and a method for preparing thereof, and more particularly, to a cell line that has an increased ability to produce virus, due to the loss of the function of the Bst-2 (tetherin) gene, and to a production method thereof. According to the present invention, a cell line lacking the function of the Bst-2 gene has an excellent ability to produce virus, compared to a wild-type cell line. Thus, when the mutant cell line is used as a virus-producing cell line, the production yield of virus can be increased. In addition, the mutant cell line can be used for the production and research of vaccines for preventing and treating viral diseases.

主权项

1. A method for preparing a virus-producing mutant cell line that is reduced from virus-induced apoptosis, the method comprising mutating a Bst-2 gene to lack the function of the Bst-2 gene in a virus-producing cell line.