PHARMACEUTICAL COMPOSITION OF BUPROPION AND NALTREXONE

摘要

A pharmaceutical composition of bupropion or salts thereof and naltrexone or salts thereof is provided. The composition comprises individual layers of bupropion or a pharmaceutically acceptable salt thereof and naltrexone or a pharmaceutically acceptable salt thereof in direct contact with each other and without being separated by any intermediate layer. A method of manufacturing the composition is also provided.

主权项

1. A pharmaceutical composition comprising:
a. a first layer comprising bupropion or a pharmaceutically acceptable salt thereof; b. a second layer comprising naltrexone or a pharmaceutically acceptable salt thereof; and c. one or more pharmaceutically acceptable excipients;wherein the composition is devoid of an intermediate layer, and wherein following ingestion of the composition by a patient, the first layer of the bupropion or a pharmaceutically acceptable salt thereof dissolves as predicted by its individual dissolution profile and the second layer of the naltrexone or a pharmaceutically acceptable salt thereof dissolves as predicted by its individual dissolution profile.