| 摘要 |
Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein R<1 >is X is -O-, -C(R<14>)2- or -N(R)-; Z is -C(R<14>)2- or -N(R)-; t is 0, 1, 2 or 3; each R and R<2 >is independently H, alkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, alkenyl or alkynyl; each R<14 >is H, alkyl, alkenyl, alkynyl, halo, -CN, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, heterocycloalkylalkyl, -OR<35>, -N(R<24>)(R<25>) or -SR<35>; R<41 >is alkyl, cycloalkyl, -SO2(alkyl), -C(O)-alkyl, -C(O)-cycloalkyl or -alkyl-NH-C(O)CH3; and the remaining variables are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula I and methods of treating cognitive or neurodegenerative diseases with compounds of formula I. Also disclosed are pharmaceutical compositions and methods of treatment comprising compounds of formula I in combination with other agents useful in treating cognitive or neurodegenerative diseases.
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