| 发明名称 |
SITE-SPECIFIC ANTIBODY-DRUG CONJUGATES |
| 摘要 |
Site-specific antibody-drug conjugates are described, in particular conjugates comprising pyrrolobenzodiazepines (PBDs) having a labile protecting group in the form of a linker. The site of conjugation, along with modification of the antiobody moiety, allows for improved safety and efficacy of the ADC. |
| 申请公布号 |
WO2016166304(A1) |
申请公布日期 |
2016.10.20 |
| 申请号 |
WO2016EP58376 |
申请日期 |
2016.04.15 |
| 申请人 |
VAN BERKEL, Patricius Hendrikus Cornelis;HOWARD, Philip Wilson |
发明人 |
VAN BERKEL, Patricius Hendrikus Cornelis;HOWARD, Philip Wilson |
| 分类号 |
A61K47/48;A61P35/00;C07K16/00;C07K16/28 |
主分类号 |
A61K47/48 |
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