| 摘要 |
<p>New esters of cephalosporins of the formula S ANGLE R1-(X1)n-CH-CO-NH-CH-CHCH2 ¦¦¦¦ Y2CO-NCH2-R2 m ANGLE C ¦ COOR3 wherein R1 is a substituted or unsubstituted alkyl, cycloalkyl, aryl or heterocyclic group, R2 is S-R4 wherein R4 is a methyl, ethyl, benzyl or heterocyclic group, a xanthate, dithiocarbamate, thiouronium, azido, alkoxy, hydrogen, substituted or unsubstituted alkanoyloxy, carbonyloxy or 1-pyridinium group, R3 is CH3OC2H5OR5O ¦ PARALLEL ¦ PARALLEL ¦ PARALLEL -CH-O-C-R6, -CH-O-C-R6, -CH-X2-C-OR7 wherein R5 is hydrogen, methyl or ethyl, X2 is O or NH, R6 is a basic group, R7 is a substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl or heterocyclic group, X1 is O or S, Y1 is hydrogen, a hydroxy, alkyloxycarbonyl, halogen, azido, a substituted or unsubstituted amino group, a carboxyl group, the group -COOR3, or a nitrite group, n is 0 or 1 and m is 0 or 1, useful as active ingredients of pharmaceutical preparations; processes for their preparation; and methods for the treatment of infectious diseases.</p> |
