| 摘要 |
<p>1314292 Prostaglandins UPJOHN CO 18 Aug 1971 [14 Sept 1970] 38782/71 Heading C2C Novel optically active prostaglandins of the formulµ or racemic compounds of those formulµ and the mirror images thereof, wherein R 1 is H, C 1-8 alkyl, or a pharmacologically acceptable cation, R 2 is CH 3 or CH 3 CH 2 , and X is -CH 2 CH 2 - or trans-CH=CH-, and both Y and Z are -CH 2 -CH 2 -, or X is trans-CH=CH-, Y is cis-CH=CH- and Z is -CH 2 -CH 2 - or cis-CH=CH- are prepared by the neutral dehydration of 15 - methyl - (or 15 - ethyl)- PGE 1 , -PEG 2 , -PGE 3 or -dihydro-PGE 1 or the C 1-8 alkyl esters thereof. Pharmaceutical compositions, suitable for parenteral administration, contain the above novel compounds together with pharmaceutically acceptable carriers. The novel compounds possess hypotensive activity and the ability to reduce and control gastric secretion and increase the flow of blood to mammalian kidney.</p> |
