Host cells with artificial endosymbionts

摘要

The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.

主权项

1. A method of detecting viability of a eukaryotic cell, comprising the steps of: providing the eukaryotic cell, wherein the eukaryotic cell comprises a magnetotactic bacterium; and imaging a magnetic property of the magnetotactic bacterium in the eukaryotic cell, whereby the viability of the eukaryotic cell is detected.