METHODS AND MATERIALS FOR PRODUCING TRANSGENIC ARTIODACTYLS

摘要

Swine animal models comprising a genomic disruption of an endogenous gene chosen from the group consisting of a Low-Density Lipoprotein Receptor gene LDLR, Duchene's Muscular Dystrophy (DMD) gene, and hairless gene (HR). Methods of preparing transfected cells useful for making a transgenic animal comprising exposing a first group of cells to a transfection agent and reseeding the group with additional cells that have not been exposed to the agent. The transgenic animals are useful for medical and scientific animal models of human diseases and conditions, as well as sources for cells, tissues, and biomaterials.

主权项

1. A transgenic livestock animal or cell comprising a genomic knockout of a gene in an artiodactyl that provides for maintenance and/or development of hair or hair growth.