发明名称 |
ANTI-INFLAMMATORY STEROIDS OF THE ANDROSTANE SERIES HAVING A HALO-SUBSTITUTED C{11 {14 C{11 {11 ALKOXY CARBONYL GROUP AT THE 17{62 {0 POSITION |
摘要 |
The Specification describes compounds of the general formula WHEREIN X represents a hydrogen, chlorine or fluorine atom; R1 represents a beta -hydroxy group, an oxo group or (when X is a chlorine atom) a beta -chlorine atom; R2 represents a hydrogen atom, a methylene group or an alpha - or beta -methyl group; R3 represents a hydrogen atom or C1-4alkyl or phenyl group; R4 represents a methyl group substituted by at least one halogen atom; an ethyl group substituted by at least one fluorine and/or iodine atom; or a propyl group substituted by at least one halogen atom; and represents a single or double bond. The Specification also describes processes for the preparation of compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I have good anti-inflammatory activity, particularly on topical application.
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申请公布号 |
US3856828(A) |
申请公布日期 |
1974.12.24 |
申请号 |
US19730379471 |
申请日期 |
1973.07.16 |
申请人 |
GLAXO LABOR LTD,GB |
发明人 |
PHILLIPPS G,GB;WOOLLETT E,GB;MAY P,GB;MCDONALD B,GB |
分类号 |
H05K13/02;A61K;A61K31/56;A61K31/565;A61P29/00;C07C;C07D;C07J;C07J1/00;C07J3/00;(IPC1-7):C07C169/24 |
主分类号 |
H05K13/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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