摘要 |
Process of reacting 1,4-dihydro-4-oxo-7-Q-1,8-naphthyridine (I) with a formylating agent to produce 1,4-dihydro-4-oxo-7-Q-1,8-naphthyridine-3-carboxaldehyde II, reacting II with a lower-alkylating agent to produce 1-(lower-alkyl)-1,4-dihydro-4-oxo-7-Q-1,8-naphthyridine-3-carboxaldehyde (III), and oxidizing III to produce 1-(lower-alkyl)-1,4-dihydro-4-oxo-7-Q-1,8-naphthyridine-3-carboxylic acid (IV), where Q is lower-alkyl, lower-alkanoyloxymethyl, 4(or 3)-pyridyl or 4(or 3)-pyridyl having one or two lower-alkyl substituents. The final products (IV) are known antibacterial agents, as are the corresponding 7-hydroxymethyl compounds which are prepared by hydrolysis of the final products where Q is 7-(lower-alkanoyloxymethyl).
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