| 摘要 |
(A) Hypoglycaemic benzenesulphonylureas X - CO - - PHENYLENE - SO2 - NH - CO-NH-R' (I) where R = H, lower alkyl, or phenylalkyl R' = (a) C2-8 alkyl or alkenyl; (b) lower phenylalkyl; (c) lower cycloalkyl; (d) endoalkylene-cyclohexyl, -cyclohexenyl, -cyclohexylmethyl or cyclohexenyl-methyl with 1-2 endomethylene C atoms; (e) lower alkylcyclohexyl, lower alkoxy-cyclohexyl; (f) C5-8 cycloalkyl; (g) cyclohexenyl, cyclohexynylmethyl X = C1-3 hydrocarbon, substd. by one or two Cl or Br-atoms or by one CN group, wherein one C atom has only one substit. Y = C1-4 alkylene. (B) Salts of (I). (C) Pharmaceutical compositions for oral administration for the treatment of diabetes mellitus contng I as active ingredient. Oral treatment of diabetes mellitus. (a) Reaction of R'NH2 with appropriately subst. |
