发明名称 |
PROCESS FOR PREPARATION OF MK-7 TYPE OF VITAMIN K2 |
摘要 |
Process for preparation of MK-7 type of vitamin K2 is characterized by attaching hexaprenyl chain of „all-trans" configuration to monoprenyl derivative of menadiol following „1 + 6" synthetic strategy. According to the invention, a-sulfonyl carbanion generated in situ from the protected monoprenyl menadiol of the formula (II), wherein R1 represents C1-3-alkyl group, is reacted with hexaprenyl halide of the formula (VII), wherein X represents halogen atom, preferably bromine, both Z' and Z' represent H or one of Z' and Z" represents H and the other represents phenylsulfonyl group -SO2Ph in the alkylation reaction. The hexaprenyl halide of formula (VII) is obtained by coupling two triprenyl units in alkylation reaction, with or without separation of the intermediates. |
申请公布号 |
TN2015000137(A1) |
申请公布日期 |
2016.10.03 |
申请号 |
TN20150000137 |
申请日期 |
2015.04.10 |
申请人 |
NATTOPHARMA R&D LTD. |
发明人 |
KRAJEWSKI, Krzysztof;KUTNER, Andrzej;DZIKOWSKA, Jadwiga;GUTOWSKA, Jadwiga;NAPIÓRKOWSKI, Marek;WINIARSKI, Jerzy;KUBISZEWSKI, Marek;JEDYNAK, Łukasz;MORZYCKI, Jacek;WITKOWSKI, Stanisław;BAJ, Aneta;WAŁEJKO, Piotr |
分类号 |
C07C315/04;C07C45/27;C07C49/683;C07C317/18 |
主分类号 |
C07C315/04 |
代理机构 |
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