PHARMACEUTICALLY USEFUL PROSTAGLANDIN DERIVATIVES

摘要

1410854 Prostaglandins SANKYO CO Ltd 24 Aug 1973 [1 Sept 1972] 40176/73 Heading C2C Novel compounds of Formula I in which A=C 4-8 alkylene, R1 = C 4-10 alkyl, R2=H or C 1-6 alkyl and R3=H or C 1-6 alkoxycarbonyl, and pharmaceutically acceptable salts thereof, are prepared by reducing a compound of Formula II in which Z=a protected carbonyl group, with a metal hydride complex reducing agent, to give a compound of Formula III removing the protecting group from the compound of Formula III and, if appropriate, salifying the product obtained. Compounds I in which R2 and R3 are both H can also be prepared by hydrolysis of a compound I in which R2= alkyl and/or R3=alkoxycarbonyl. The corresponding groups can also be removed from compounds III, to give compounds in which R2=R3=H. Starting materials of Formula II and intermediates therefor are prepared as shown in the following reaction scheme Pharmaceutical compositions having oxytocic activity, for parenteral administration, comprise a compound I, or a pharmaceutically acceptable salt thereof, and a pharmaceutical carrier or diluent.