Antiulcer agents contg amino-substd benzylamines - e.g. 2-amino-3-bromo-5- carbethoxy-N,N-diethyl-benzylamine

摘要

Antiulcer agents contain one or more amino-substd. benzylamines of formula (I) (where R1 is H or acetyl; R2 is H, Cl or Br; R3 is F, 1-4C alkyl, CF3, CN, carbamoyl, COOH, COEt, OCH3, COCH3, -CHOH-CH3 or a group -CH2-NR6R7 in which R6 and R7 are CH3, cyclohexyl or hydroxycyclohexyl, or NR6R7 is pyrrolidino, piperidino or morpholino; and R4 and R5 are CH3, C2H5, cyclohexyl or hydroxycyclohexyl, or NR4R5 is pyrrolidino, piperidino, hexamethyleneimino, morpholino or 4-methyl-1-piperazinyl) or their physiologically tolerable salts with inorganic or organic acids, e.g. 2-amino-3-bromo-5-carbethoxy-N,N-diethyl-benzylamine hydrochloride, generally in an amount of 25-100 mg (pref. 30-60 mg). Daily dosage of (I) is generally 75-400 mg, pref. 90-240 mg. Dosage forms include tablets, dragees, capsules and solutions.