4-Phenyl-piperazino-alkyl anthranilate deriv prepn. - from 2-nitro-benzoic acid via acid halide or salts, condensation with phenyl-piperazino-alkyl radical and reduction

摘要

Process for the preparation of cpds. (I) using the following stages: -preparation of an acid halide of 2-nitro-benzoic acid or its alkali metal or tertiary base salts an condensation of this acid halide or salt with the substd. phenyl-piperazino-alkyl radical of (I). These reactions may be effected in one stage or in two or three successive stages. The nitro group is reduced to amino at the end of this reaction sequence or during it. where A = opt. branched 1-5C alkylene, R = halo, trihalomethyl, trihalomethoxy or trihalomethylthio. Parent patent states cpds. are analgosics. Present process gives good yields by simple methods.