Production of 2-(thio substituted)cephalosporin sulfoxides and 2-(thio substituted)cephalosporins

摘要

A new method of producing 2-(thio substituted) cephalosporin derivatives comprises treating a cephem sulfoxide with an electrophilic sulfur reagent in the presence of a strong base. The cephem sulfoxides produced by this step are useful as intermediates, which by reduction of the sulfoxide group, yield 2-(thio substituted) cephalosporins having useful antimicrobial activity.