Caffeine derivatives

摘要

New derivatives of caffeine are disclosed having the formula: WHERE R1, R2, R3 and R4 are selected from the group consisting of hydrogen, chlorine, bromine, an alkyl or an alkoxy radical containing from 1 to 4 carbon atoms. They are made by transforming 8- alpha hydroxyethyl caffeine into the corresponding 8- alpha -chloroethyl caffeine by the action of a suitable chlorinating agent such as thionyl chloride, reacting the product so obtained in a suitable solvent such as anhydrous dimethylformamide at a temperature from 40 DEG to 110 DEG C and for a period of time from 1 to 5 hours with the sodium or potassium salt of a nicotinic acid of the formula: