发明名称 |
Chitosan derivatives for inactivation of endotoxins and surface protection of nanoparticles |
摘要 |
The present disclosure provides a polymer comprising a derivative of chitosan, wherein the derivative is zwitterionic, as well as methods of using the polymer. In addition, the present disclosure provides a nanoparticle structure comprising a derivative of chitosan and a dendrimer, as well as methods of utilizing the nanoparticle structure. |
申请公布号 |
US9517246(B2) |
申请公布日期 |
2016.12.13 |
申请号 |
US201615212771 |
申请日期 |
2016.07.18 |
申请人 |
PURDUE RESEARCH FOUNDATION |
发明人 |
Yeo Yoon;Bajaj Gaurav;Xu Peisheng;Liu Karen;Cho Eun Jung |
分类号 |
C08L5/08;C08L79/02;A61K31/722;A61K47/48 |
主分类号 |
C08L5/08 |
代理机构 |
Wenderoth, Lind & Ponack, L.L.P. |
代理人 |
Wenderoth, Lind & Ponack, L.L.P. |
主权项 |
1. An anti-tumor nanoparticle comprising a non-covalent, electrostatic complex between (1) a conjugate comprising a poly(amidoamine) dendrimer (PAMAM dendrimer) and an anti-tumor agent and (2) a zwitterionic chitosan derivative having an anhydride to amine (An/Am) ratio of 0.3 to 0.7, wherein (A) the zwitterionic chitosan derivative was synthesized by partial amidation of a chitosan with succinic anhydride, (B) the weight ratio of zwitterionic chitosan derivative to PAMAM dendrimer is greater than or equal to 1 but less than or equal to 4, and (C) the size of the anti-tumor nanoparticle is between 250 nm and about 500 nm. |
地址 |
West Lafayette IN US |