Method of using a miR172 Molecule for Decreasing Inflammation

摘要

An exemplary embodiment relates to a method of using a plant-derived miR172 molecule or its synthetic equivalent, selected from amongst miR172a or miR172b, for decreasing inflammatory processes in an organism, a method of decreasing B and T lymphocyte proliferation, as well as a method of reducing protein FAN (Factor Associated with Neutral Sphingomyelinase Activation) level. Exemplary embodiments provide a novel therapeutic method based on miRNA molecules, which through the interaction with mRNA encoding FAN protein, negatively regulate its expression and decrease the inflammatory response of the organism.

主权项

1. A method comprising:
administering to a living organism a plant-derived miR172 molecule or its synthetic equivalent,
wherein the molecule is selected from amongst miR172a or miR172b,
wherein miR172a is represented by the sequence SEQ. ID No. 1, andwherein miR172b by the sequence SEQ. ID No. 2,wherein the molecule has at least 6 out of 7 nucleotides present in a seed region represented by the sequence GAAUCUU,wherein the molecule has at least 75% sequence similarity to SEQ. ID No. 1 or SEQ. ID No. 2, in an amount sufficient to at least one of:
decrease orlimit increase,of an inflammatory response of the living organism.